2MeV注入器脉冲电子束时间分辨能谱诊断研究

 介绍了利用磁分析器和电子束产生的契伦科夫辐射光诊断直线感应加速器脉冲电子束时间分辨能谱的原理、方法及诊断系统，对中物院2MeV感应叠加型注入器的2kA强流脉冲电子束时间分辨能谱进行实验诊断，并与二极管电压进行对比分析。测得能量约2.2MeV，60ns内最大能量变化为4%。     

MgO在Mg-hBN体系中对合成cBN晶体的影响

 以金属镁粉为触媒，以六角氮化硼为原料，其中加入适量比例的氧化镁，在国产六面顶压机上，在约5.0 GPa压力、1 500～1 800 K温度条件下，合成出了颜色均匀、晶形完整的黄色立方氮化硼单晶体。实验结果表明，在Mg-hBN体系中，氧化镁对合成cBN晶体的颜色及合成温度有很大的影响。     

利用喇曼光谱测量氧碘化学激光器氯气利用率的实验研究

 介绍了利用自发喇曼散射光谱测量氧碘化学激光器单态氧发生器氯气利用率的原理及实验装置，并给出了在以氮气作为稀释气的0.1mol/s射流式氧发生器上测试的结果，测试相对误差小于12%。由于该方法只需要通过测量喇曼谱线相对强度之比，即可算出氯的利用率，因此不需要另外的标定实验，从而避免了因标定带来的影响。该方法减小了测试误差，简化了实验过程，提高了测试效率。     

巯基乙酸锑配合物的合成与X射线粉末衍射数据指标化

一些锑和铋的配合物可以应用于医药研究[1,2 ] ,已合成了许多锑的有机配体配合物[3～ 7] ,但其中大多数没有生物活性。因此 ,研究锑或铋离子的配合物不仅对主族元素化学、生物无机化学而且对医药都有着非常重要的意义。我们用三氯化锑与巯基乙酸液相反应法合成的二巯基乙酸锑 (Ⅲ)配合物 ,其组成为ＨＳｂ(ＳＣＨ2 ＣＯＯ) 2 ,用Ｘ射线粉末多晶衍射数据指标化来研究配合物晶体结构[8] 。1　实验部分1 1　仪器与试剂ＥＡ - 1 1 0 6型元素分析仪 (意大利卡拉欧巴公司制造 ) ,Ｄ Ｍａｘ -ＹＢ型多晶Ｘ射线粉末衍射仪(日本理学 ,ＣｕＫα射线 ,…     

MILO中场不稳定性的非线性发展及混沌行为

 以磁绝缘传输线振荡器中电子运动和辐射场演化方程为基础，分析了场与电子相互作用过程中的不稳定性。这种不稳定性的发展导致场出现极限环振荡和混沌。在软非线性区域，辐射场表现为不连续的极限环振荡；在硬非线性区域，辐射场表现为连续的混沌行为。控制失谐量可加速或抑制这些不稳定态的出现。优化和调节参数可控制器件的运行状态, 获得较高的输出功率。     

中国上市公司资本结构影响因素之实证研究

资本结构不仅是财务理论研究中的热点及难点,也日益成为公司理财决策的关键问题.本文从影响因素角度对资本结构进行实证研究.文中以深沪两市部分非金融类上市公司为样本,利用本世纪最初三年的企业财务数据,选取可能影响企业资本结构的多个指标为解释变量,利用单因素方差分析、主成分分析、逐步回归分析找出了主要影响因素及其影响方式,试图为国内上市公司资本结构决定因素提供最新实证研究证据,并为企业财务决策提供支持.     

A rapid UPLC‐MS/MS method for the determination of oleanolic acid in rat plasma and liver tissue: application to plasma and liver pharmacokinetics

A reliable high‐throughput ultra‐high performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed and validated for oleanolic acid (OA) determination in rat plasma and liver tissue using glycyrrhetic acid as the internal standard (IS). Plasma and liver homogenate samples were prepared using solid‐phase extraction. Chromatographic separation was achieved on a C₁₈ column using an isocratic mobile phase system. The detection was performed by multiple reaction monitoring mode via positive electrospray ionization interface. The calibration curves showed good linearity (R² > 0.9997) within the tested concentration ranges. The lower limit of quantification for plasma and liver tissue was ≤0.75 ng/mL. The intra‐ and inter‐day precision and accuracy deviations were within ±15% in plasma and liver tissue. The mean extraction recoveries ranged from 80.8 to 87.0%. In addition, the carryover, matrix effect, stability and robustness involved in the method were also validated. The method was successfully applied to the plasma and hepatic pharmacokinetics of OA after oral administration to rats. Copyright © 2015 John Wiley & Sons, Ltd.     

亲水性相互作用色谱-串联质谱联用法检验鱼塘水中的草甘膦

建立了亲水性相互作用色谱-串联质谱联用法检验鱼塘水中草甘膦的方法。样品经去离子水提取,C18固相萃取柱和滤膜净化后,以0.5%异丙胺-乙腈为流动相,亲水性相互作用色谱柱分离,负离子扫描和多反应监测模式质谱监测,基质匹配标准溶液外标法定量。草甘膦质量浓度在10～1000 ng/mL范围内线性良好(r≥0.9973),日内、日间精密度RSD≤10%(n=5),鱼塘水中草甘膦的回收率在90%以上。该方法不需衍生化,净化步骤简便快捷,定量准确,可满足侦查和诉讼中草甘膦的检测要求。     

Divergent Syntheses of Fused β‐Naphthol and Indene Scaffolds by Rhodium‐Catalyzed Direct and Decarbonylative Alkyne–Benzocyclobutenone Couplings

A tunable rhodium‐catalyzed intramolecular alkyne insertion reaction proceeding through the C? C cleavage of benzocyclobutenones is described. Selective formation of either the direct or decarbonylative insertion product can be controlled by using different catalytic systems. A variety of fused β‐naphthol and indene scaffolds were obtained in good yields with high functional group tolerance. This work illustrates a divergent approach to synthesize fused‐ring systems by C? C activation/functionalization.     

Pathway from N‐Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2‐Oxoglutarate‐Dependent Oxygenases

N‐alkylisonitrile, a precursor to isonitrile‐containing lipopeptides, is biosynthesized by decarboxylation‐assisted ‐N≡C group (isonitrile) formation by using N‐alkylglycine as the substrate. This reaction is catalyzed by iron(II) and 2‐oxoglutarate (Fe/2OG) dependent enzymes. Distinct from typical oxygenation or halogenation reactions catalyzed by this class of enzymes, installation of the isonitrile group represents a novel reaction type for Fe/2OG enzymes that involves a four‐electron oxidative process. Reported here is a plausible mechanism of three Fe/2OG enzymes, Sav607, ScoE and SfaA, which catalyze isonitrile formation. The X‐ray structures of iron‐loaded ScoE in complex with its substrate and the intermediate, along with biochemical and biophysical data reveal that ‐N≡C bond formation involves two cycles of Fe/2OG enzyme catalysis. The reaction starts with an Fe^IV‐oxo‐catalyzed hydroxylation. It is likely followed by decarboxylation‐assisted desaturation to complete isonitrile installation.